Sympathetic dysregulation in heart failure: Mechanisms and therapy
نویسندگان
چکیده
منابع مشابه
Brain mechanisms contributing to sympathetic hyperactivity and heart failure.
It is well recognized that the initial myocardial injury and associated decrease in left ventricular (LV) function activate progressively a variety of systems, which in the longterm contribute to progressive cardiac dysfunction and clinical heart failure. Studies on the pathophysiology of the CHF syndrome have extensively focused on the activity of systems such as the sympathetic nervous system...
متن کاملNovel mechanisms of sympathetic regulation in chronic heart failure.
The idea that activation of the sympathetic nervous system is part and parcel of the apparent positive feedback cycle of cardiac deterioration in the setting of chronic heart failure (CHF) is not a new one. Several reviews have clearly summarized the evidence for this concept using both clinical data and information from experimental models.1–4 Evidence from both neural recordings and measureme...
متن کاملThe sympathetic nervous system and heart failure.
Heart failure (HF) is a syndrome characterized by upregulation of the sympathetic nervous system and abnormal responsiveness of the parasympathetic nervous system. Studies in the 1980s and 1990s demonstrated that inhibition of the renin-angiotensin-aldosterone system with angiotensin-converting enzyme inhibitors improved symptoms and mortality in HF resulting from systolic dysfunction, thus pro...
متن کاملSympathetic nervous system in heart failure.
For those who have comfortably accepted the mechanistic link between sympathetic nervous system activation and poor outcome in heart failure, the study by Brede et al1 in this issue of Circulation is a welcome confirmation. The authors appear to have demonstrated in a murine model that absence of sympathoinhibitory 2 adrenoreceptors is associated with overactive catecholamine release, aggressiv...
متن کاملExcessive sympathetic activation in heart failure with obesity and metabolic syndrome: characteristics and mechanisms.
Congestive heart failure is characterized by sympathetic activation, which has also been described in the metabolic syndrome. No information exists, however, as to whether the sympathostimulating effects of these 2 conditions summate when heart failure is complicated by the metabolic syndrome, leading to an exceedingly high adrenergic drive. This is clinically relevant, because in heart failure...
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ژورنال
عنوان ژورنال: Clinical Cardiology
سال: 1995
ISSN: 0160-9289,1932-8737
DOI: 10.1002/clc.4960181303